Thursday, December 27, 2012

epistasis and evolution

"These data indicate that epistasis is pervasive throughout protein evolution: about 90 per cent of all amino-acid substitution have a neutral or beneficial impact only in the genetic backgrounds in which they occur, and must therefore be deleterious in a different background of other species." http://www.nature.com/nature/journal/v490/n7421/full/nature11510.html

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